Cooperation Partner

DZD Deutsches Zentrum für Diabetes Forschung (German Center for Diabetes Research)

     

The German Center for Diabetes Research (DZD) brings together experts in the field of diabetes research and combines basic research, translational research, epidemiology and clinical applications. The aim of the DZD is to develop novel strategies for successful, personalized detection, prevention and treatment of diabetes and its complications. Members of the DZD are Helmholtz Zentrum München - German Research Center for Environmental Health, the German Diabetes Center in Düsseldorf, the German Institute of Human Nutrition in Potsdam-Rehbrücke, the Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Medical Center Dresden and the Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Zentrum München at the University of Tuebingen together with associated partners at the Universities in Heidelberg, Cologne, Leipzig, Lübeck and Munich.

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We would like to thank the DZD for supporting this year`s Helmholtz Diabetes Lecture! 

CRC 1118 “Reactive Metabolites as a cause of diabetes complications”

The CRC 1118 “Reactive Metabolites as a cause of diabetes complications” is an interdisciplinary network of researchers that investigates the cause and development of late complications in diabetic disorders.

It has been shown that the development of complications can neither be explained or predicted solely by an individual’s blood glucose or HbA1c.

The CRC 1118 seeks to understand this disconnection between glucose and complications by focusing on the role of intracellular reactive metabolites in mediating cellular dysfunction and organ damage.

To achieve this aim, the consortium has three corner stones; the first tries to understand the mechanisms by which reactive metabolites are increased and accumulate in diabetes. The second is the study of how reactive metabolites induce cellular dysfunction through interactions with the DNA and proteins of a cell and the third studies the enzymatically-dependent pathways which control the formation and accumulation of reaction metabolites.

Through these corner stones it is anticipated that the development of complications can be prevented and that already existing complications would be driven into remission.

CRC 1118 is supported by the German Research Foundation (DFG).

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