CRC 1118 “Reactive Metabolites as a cause of diabetes complications”
The CRC 1118 “Reactive Metabolites as a cause of diabetes complications” is an interdisciplinary network of researchers that investigates the cause and development of late complications in diabetic disorders.
It has been shown that the development of complications can neither be explained or predicted solely by an individual’s blood glucose or HbA1c.
The CRC 1118 seeks to understand this disconnection between glucose and complications by focusing on the role of intracellular reactive metabolites in mediating cellular dysfunction and organ damage.
To achieve this aim, the consortium has three corner stones; the first tries to understand the mechanisms by which reactive metabolites are increased and accumulate in diabetes. The second is the study of how reactive metabolites induce cellular dysfunction through interactions with the DNA and proteins of a cell and the third studies the enzymatically-dependent pathways which control the formation and accumulation of reaction metabolites.
Through these corner stones it is anticipated that the development of complications can be prevented and that already existing complications would be driven into remission.
CRC 1118 is supported by the German Research Foundation (DFG).
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